How Skin Substitutes Can Help Diabetic Patients Heal Wounds

For individuals living with diabetes, wound healing can be a significant challenge. Diabetic patients often face complications that impair their body’s natural healing processes, leading to chronic wounds that are slow to heal and prone to infection. These wounds, particularly on the feet and lower legs, can have severe consequences if left untreated, potentially leading to amputation in extreme cases. However, advancements in medical technology have brought forth innovative solutions to address this critical issue. 

Among these breakthroughs, skin substitutes have emerged as a promising treatment option, offering new hope for diabetic patients struggling with persistent wounds. These bioengineered products mimic the structure and function of human skin, providing a scaffolding for the body’s healing processes and dramatically improving wound closure rates.


Before delving into the benefits of skin substitutes, it’s crucial to understand why diabetic wounds are particularly challenging to heal. Diabetes affects the body in several ways that impair wound healing:

  • Poor circulation – Diabetes can cause peripheral artery disease, reducing blood flow to extremities and slowing the delivery of oxygen and nutrients essential for healing.
  • Neuropathy – Nerve damage can lead to a loss of sensation, making it difficult for patients to notice and address wounds early.
  • Impaired immune function – High blood sugar levels can weaken the immune system, increasing the risk of infection in wounds.
  • Cellular dysfunction – Diabetes can affect the function of cells involved in the healing process, such as fibroblasts and keratinocytes.

These factors combined often result in chronic, non-healing wounds that can persist for months or even years, significantly impacting a patient’s quality of life and increasing the risk of serious complications.


Before delving into the benefits of skin substitutes, it’s crucial to understand why diabetic wounds are Skin substitutes are bioengineered products designed to mimic the structure and function of human skin. They serve several critical purposes in the wound-healing process:

  • Providing a protective barrier – Skin substitutes temporarily cover the wound, protecting it from external contaminants and maintaining a moist healing environment.
  • Promoting cell migration and proliferation – These products provide a scaffold that encourages the migration of the patient’s own cells into the wound bed, promoting tissue regeneration.
  • Delivering growth factors – Many skin substitutes contain growth factors and other bioactive molecules that stimulate healing and tissue repair.
  • Reducing inflammation – Some skin substitutes have anti-inflammatory properties, helping to manage the chronic inflammation often present in diabetic wounds.
  • Improving vascularization – Certain skin substitutes promote the formation of new blood vessels, improving circulation to the wound area.

There are several types of skin substitutes available, each with unique properties:

  • Acellular dermal matrices
  • Living cell-based products
  • Biosynthetic substitutes
  • Composite substitutes 

The choice of skin substitute depends on various factors, including the wound type, size, and the patient’s overall health condition.


Skin substitutes offer several advantages for diabetic patients with chronic wounds:

  • Accelerated healing – Many studies have shown that skin substitutes can significantly speed up wound closure compared to standard care alone.
  • Reduced risk of infection – Providing a protective barrier helps reduce the risk of wound infection, a common complication in diabetic patients.
  • Decreased pain – Patients often experience less pain and discomfort as the wound heals more quickly.
  • Improved quality of life – Faster healing means patients can resume their normal activities sooner, enhancing overall quality of life.
  • Cost-effective in the long run – While these products may have a higher upfront cost, their ability to promote faster healing can reduce overall treatment costs and prevent costly complications.
  • Reduced need for amputation – These can help prevent the need for amputation in severe cases by promoting healing in chronic wounds.

The application of skin substitutes typically involves the following steps:

  • Regular check-ups are necessary to monitor the healing progress and replace the skin substitute as needed.
  • The wound is thoroughly cleaned and debrided to remove any dead tissue or debris.
  • The skin substitute is cut to fit the wound size and carefully placed over the wound bed.
  • The substitute is secured in place, often using sutures, staples, or specialized dressings.

At Acesso Biologics, we are committed to providing innovative skin substitutes and products designed to accelerate wound healing in diabetic patients. Our range of proven solutions incorporates cutting-edge technology to address the unique challenges of diabetic wounds.


Our dedication to research and development ensures that we remain at the forefront of advanced wound care technologies. Healthcare providers can offer their patients our state-of-the-art wound care solutions that enhance healing, reduce complications, and improve quality of life. For more information on our skin substitutes and other wound care products, contact us through our Online Form or call us at 775.762.8068.

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